ABOUT PKRRATING

3B). R526 with the loop among αJ and αI anchors the C-terminal part of the activation loop by forming a salt bridge with E458 at The bottom of αEF. Q459 stabilizes the HRD motif by a hydrogen bond to the leading chain carbonyl of R413. The suggestion in the activation segment is stabilized by a hydrogen bond involving Y454 and E480 from αF. ins